Johanna DiStefano, Ph.D.

Dr. Johanna DiStefano directs innovative research into the molecular mechanisms that drive chronic metabolic diseases. With more than two decades of experience, her work focuses on type 2 diabetes (T2D) and its associated complications, including metabolic dysfunction-associated steatotic liver disease (MASLD), diabetic dyslipidemia, and diabetic kidney disease. Supported by numerous NIH-funded studies, her research aims to address critical gaps in understanding these complex conditions and improve outcomes for affected individuals. The longstanding goal of her scientific program is to conduct research leading to 1) an enhanced mechanistic understanding of complex disease processes, 2) early and noninvasive diagnostic assays to identify at-risk individuals for preventative strategies, 3) individualized treatment strategies in the clinical management of disease, and 4) identification of targets for the development of new and improved therapeutics.
 
Dr. DiStefano’s current efforts investigate the progression of MASLD in both children and adults, metabolic improvements following bariatric surgery, and the role of extracellular vesicles (EVs) in obesity-related metabolic dysfunction. By studying EV content and its role in mediating metabolic changes, her team explores novel mechanisms behind the benefits of lifestyle and surgical interventions. Collaborating with ethnically diverse patient populations, she employs advanced tools such as high-throughput sequencing, functional genomics, EV profiling, and DNA methylation analysis to bridge basic science and clinical application.
 
Dr. DiStefano has contributed to over 125 scientific articles and book chapters, reflecting her dedication to advancing metabolic research. She serves as Associate Editor for BMJ Open Gastroenterology and sits on the Editorial Boards of BMC Medicine, Noncoding RNA, and Review of Diabetic Studies. As a frequent NIH grant reviewer and participant in multi-center research collaborations, she is deeply engaged in shaping the field.
 
Beyond her research, Dr. DiStefano is committed to mentoring the next generation of scientists, having guided more than 50 trainees at various career stages. She holds an Adjunct Faculty position at Arizona State University and contributes to national initiatives, such as the Study of Women’s Health Across the Nation (SWAN). Her collaborative work extends to global partnerships, including a previous Visiting Professorship at Catholic University in Rome, Italy.
 
When not engaged in her research, Dr. DiStefano volunteers as a hospice caregiver, enjoys hiking through Arizona’s stunning landscapes, and practices classical piano.