Nicholas J. Schork is Distinguished Professor and Director of the Division of Clinical Genomics and Therapeutics at The Translational Genomics Research Institute (TGen) in Phoenix, AZ. Dr. Schork is also Adjunct Professor of Population Sciences as well as Molecular and Cellular Biology at City of Hope; Adjunct Professor of Psychiatry and Biostatistics at the University of California San Diego; and Adjunct Professor of Integrative Structural and Computational Biology at Scripps Research.
Prior to his current positions, Dr. Schork was Professor and Director of Human Biology at the J. Craig Venter Institute; Professor, Molecular and Experimental Medicine, at The Scripps Research Institute (TSRI) and Director of Bioinformatics and Biostatistics for the Scripps Translational Science Institute (STSI). Dr. Schork has also held faculty appointments at Case Western Reserve University (CWRU) and Harvard University. Between 1999 and 2000 Dr. Schork took a leave of absence from CWRU to conduct research as Vice President of Statistical Genomics at the French Biotechnology company, Genset, where he helped guide efforts to construct the first high-density map of genetic variation in the human genome.
Dr. Schork has published over 600 articles in many areas of biomedical and translation science, including articles detailing novel methodologies and applications leveraging integrated approaches to disease diagnosis, treatment, and prevention, as well as clinical trials design. He also has a long history of collaborative and consortium-related research in which he has contributed analysis methodology and applied data analysis expertise. For example, Dr. Schork is the Principal Investigator for the NIA-funded Longevity Consortium, whose goals are to identify and characterize factors that contribute to human longevity. Dr. Schork has 12 patents associated with genetic analysis methodology, been involved with more than 10 start-up companies, and has mentored over 75 students and post-doctoral fellows.
Select Publications
The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank. Don J, Schork AJ, Glusman G, Rappaport N, Cummings SR, Duggan D, Raju A, Hellberg KG, Gunn S, Monti S, Perls T, Lapidus J, Goetz LH, Sebastiani P, Schork NJ. Geroscience. 2024 Aug;46(4):3911-3927. Epub 2024 Mar 7.
Single-Cell Patch-Clamp/Proteomics of Human Alzheimer's Disease iPSC-Derived Excitatory Neurons Versus Isogenic Wild-Type Controls Suggests Novel Causation and Therapeutic Targets. Ghatak S, Diedrich JK, Talantova M, Bhadra N, Scott H, Sharma M, Albertolle M, Schork NJ, Yates JR 3rd, Lipton SA. Adv Sci (Weinh). 2024 Aug;11(29):e2400545. Epub 2024 May 21.
Pentadecanoic Acid (C15:0), an Essential Fatty Acid, Shares Clinically Relevant Cell-Based Activities with Leading Longevity-Enhancing Compounds. Venn-Watson S, Schork NJ. Nutrients. 2023 Oct 30;15(21):4607.
A CRISPR-enhanced metagenomic NGS test to improve pandemic preparedness. Chan AP, Siddique A, Desplat Y, Choi Y, Ranganathan S, Choudhary KS, Khalid MF, Diaz J, Bezney J, DeAscanis D, George Z, Wong S, Selleck W, Bowers J, Zismann V, Reining L, Highlander S, Brown K, Armstrong JR, Hakak Y, Schork NJ. Cell Rep Methods. 2023 Apr 18;3(5):100463. eCollection 2023 May 22.
Exploring human biology with N-of-1 clinical trials. Schork NJ, Beaulieu-Jones B, Liang WS, Smalley S, Goetz LH. Camb Prism Precis Med. 2023;1:e12. Epub 2023 Jan 10.
See also: PubMed listing
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