Dr. Yue Hao is a Research Assistant Professor in the Berens and Barthel Labs. Her research focuses on the genomic evolution of glioblastoma (GBM) and the identification of vulnerability signatures for targeted therapies. GBM is one of the most aggressive and treatment-resistant brain tumors, driven by its heterogeneity. Dr. Hao seeks to uncover the mechanisms underlying GBM tumor initiation, progression, recurrence, and therapeutic resistance. She explores tumor evolution, the tumor microenvironment (TME), and tumor–immune interactions using advanced genomic and transcriptomic techniques. Through single-cell and spatial transcriptomics, she investigates sex-based differences in the immune landscape of the GBM TME. Additionally, she employs long-read sequencing to study how telomere dysfunction contributes to structural variations in glioma cell lines over time. Together, these efforts aim to reveal key mechanisms of tumor progression and resistance, identify novel therapeutic targets, and advance precision medicine for brain cancer.
Dr. Hao earned her Ph.D. in Bioinformatics from North Carolina State University in 2020, followed by postdoctoral research at the Center for Mechanisms of Evolution within the Biodesign Institute at Arizona State University. In 2022, she joined TGen, where she continues her research at the intersection of genome evolution and translational cancer science.
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