The purpose of this study is to identify the molecular basis of SCCO, and translate this information into effective treatments for SCCO patients. We plan to achieve this goal by first collecting SCCO tumors and blood from SCCO patients. As SCCO tumors are extremely rare, we are reaching out globally to collect these specimens from SCCO patients, or from legal guardians of patients who have succumbed to this disease. Once specimens have been obtained, researchers will apply state-of-the art genomic approaches to better understand why girls and young women develop SCCO. It is hoped that this research will lead to the development of new, effective treatments for patients newly diagnosed with SCCO.
The Translational Genomics Research Institute (TGen) houses an array of technologies necessary to understand more fully how tumors develop and grow. TGen scientists are skilled in manipulating high-resolution genomic data to define new rationales for optimal treatment selection for SCCO patients.
In 2013, TGen obtained IRB approval to collect a DNA sample from biological relatives of SCCO patients participating in this study. While the cause of SCCO is not understood, it is possible DNA information from blood relatives may provide important clues to understand the basis of this disease.
Small cell carcinoma of the ovary (SCCO) is an aggressive form of ovarian cancer. SCCO affects adolescent girls and young women at an average age of 23.5 years with the youngest patient diagnosed at 14 months. Less that 1% of all ovarian cancers are diagnosed as SCCO. The molecular basis of how SCCO tumors develop and progress is not known.
Voluntary Participation in SCCO Research
If you are an SCCO patient, guardian of a patient who has succumbed to their disease, or blood relative of an SCCO patient enrolled in the TGen study and would like to participate in this voluntary SCCO-specific research study, please click the participant instructions link above.
There are a number of sites and resources for patients and families faced with a diagnosis of SCCO. Below are a few that provide information, forums, clinical trials, and opportunities to connect with others who have similar questions and share the same concerns.
Small Cell Ovarian Cancer Foundation
The Ovarian Cancer National Alliance
National Cancer Institute
SCCO Study Contact
Translational Genomics Research Institute
Tel (602) 343-8653